Laboratory of Cellular and Tissue Physiology
Department of Developmental Biology, Stanford University School of Medicine
We study the fundamental principles of how biological systems maintain their function over time and why resilience eventually fails with age. Bridging engineering, computation, and biology, we develop and apply technologies to map and control physiological function across multiple scales within living animals. Ultimately, we aim to create new ways of enhancing resilience, slowing aging-related decline, and restoring lost function.
Mechanisms of Resilience
We study how biological systems maintain function despite stress and damage. By systematically mapping molecular and cellular mechanisms of resilience, we aim to identify key pathways that protect cells and tissues throughout life. This will reveal how are coordinated across cell types, adapt to environmental challenges, and fail with age.
Reading & Writing Biology
We develop new technologies to measure and manipulate genes and cells at an unprecedentedly high resolution and large scale in living animals. By integrating imaging, functional genomics, and AI, we aim to systematically understand how genetic and environmental factors shape cellular function within intact tissues, and to program new functionalities into cells in vivo.
Engineering Cells & Tissues
Our long term goal is to translate fundamental insights into novel interventions that enhance resilience or restore lost function. Leveraging new technologies and discoveries, we aim to build upon the body's intrinsic capacity for adaptation and repair: to slow age-related decline, treat chronic disease, and potentially rejuvenate old tissue.